Ian Nicastro, Ph.D.



Ph.D., Biology, University of California, San Diego, 2012

BS, Neuroscience & Animal Physiology, University of California, San Diego, 2004


In addition to serving as the Pasquinelli Lab Manager, Ian conducts research on how components of the miRNA pathway influence aging and health. He specializes in lifespan studies, fluorescence microscopy, and creation of strains through microinjection. Ian has a research background in neurodegenerative diseases associated with aging, nutrition, and behavioral pharmacology. He is also an avid collector of mineral specimens.

Sustainability Articles

Ian's interview for Lab Manager Magazine: A More Holistic Approach to Laboratory Resource Reduction [Link]

Ian's interview for Promega Connections: Lab Sustainability Doesn’t Have To Be Painful [Link]


Aalto AP*, Nicastro IA*, Broughton JP, Chipman LB, Schreiner WP, Chen JS, & Pasquinelli AE. (2018). Opposing roles of microRNA Argonautes during Caenorhabditis elegans aging PLOS Genetics [Link]

Nicastro, I., Dillin, A. (2013). Proteostasis and the aging pathways in Morimoto, R., Christen, Y., Protein Quality Control in Neurodegenerative Diseases, Research and Perspectives in Alzheimer's Disease (pp 37-52). Berlin, Heidelberg: Springer-Verlag.

Kindt, K.S., Quast, K.B., Giles, A.C., De, S., Hendrey, D., Nicastro, I., Rankin, C.H., Schafer, W.R. Dopamine mediates context-dependent modulation of sensory plasticity in C. elegans. Neuron. 2007 Aug 16;55(4):662-76.